Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effect of Acetylcholine and Adenosine on Cardiac Cellular Potentials

Nature volume 178, pages 1174–1175 (1956)Cite this article

Abstract

WE have been impressed by the similarity of the effects of acetylcholine and adenosine on the membrane-resting and action potentials of guinea pig myocardial fibres. There are a number of reports of the effects of acetylcholine on the membrane-resting and action potentials of myocardial fibres1–4; but we have seen no report on the effects of adenosine or of their similarity to those of acetylcholine.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Burgen, A. S. V., and Terroux, K. G., J. Physiol., 120, 449 (1953).

    Article  CAS  Google Scholar 

  2. Hoffman, B. F., and Suckling, E. E., Amer. J. Physiol., 173, 312 (1953).

    CAS  Google Scholar 

  3. Woodbury, J. W., and Brady, A. J., Science, 123, 100 (1956).

    Article  ADS  CAS  Google Scholar 

  4. Leyden Webb, J., and Hollander, P. B., Circ. Res., 4, 332 (1956).

    Article  Google Scholar 

  5. Johnson, E. A., J. Pharmacol. and Exp. Therap., 117, 237 (1956).

    CAS  Google Scholar 

  6. Rand, M., and Stafford, A., Arch. Int. Pharmacodyn. (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Sydney,

    EDWARD A. JOHNSON & M. G. McKINNON

Authors
  1. EDWARD A. JOHNSON
    View author publications

    Search author on:PubMed Google Scholar

  2. M. G. McKINNON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

JOHNSON, E., McKINNON, M. Effect of Acetylcholine and Adenosine on Cardiac Cellular Potentials. Nature 178, 1174–1175 (1956). https://doi.org/10.1038/1781174a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/1781174a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing