Abstract
DIMETHYLNITROSAMINE is a powerful liver poison and carcinogen1,2, the mode of action of which is being studied in these Laboratories. As part of this programme, we have investigated the metabolic products from rats and mice using (14C) dimethylnitrosamine3.
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References
Barnes, J. M., and Magee, P. N., Brit. J. Indust. Med., 11, 167 (1954).
Magee, P. N., and Barnes, J. M., Brit. J. Cancer (in the press).
Dutton, A. H., and Heath, D. F., J. Chem. Soc. (in the press).
Miller, E. C., Plescia, A. M., Miller, J. A., and Heildelberger, C., J. Biol. Chem., 196, 863 (1952).
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DUTTON, A., HEATH, D. Demethylation of Dimethylnitrosamine in Rats and Mice. Nature 178, 644 (1956). https://doi.org/10.1038/178644a0
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DOI: https://doi.org/10.1038/178644a0
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