Abstract
INOCULATION of a chick embryo-adapted MEF 1 strain of poliomyelitis virus into the yolk sac of chick embryos produces an infection which causes lesions like those observed in primates infected with poliomyelitis1. Preliminary studies did not reveal the exact mode of spread of the virus from the yolk sac to the nervous system. The present experiments were designed to elucidate this point by correlating the distribution of histological lesions with the concentration of virus in various tissues during the early stages of infection after introduction of poliomyelitis virus by the yolk sac and by the intravenous routes.
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References
Love, R., and Roca-Garcia, M., Amer. J. Path., 31, 901 (1955).
Roca-Garcia, M., Moyer, A. W., and Cox, H. R., Proc. Soc. Exp. Biol. and Med., 81, 519 (1952).
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LOVE, R., ROCA-GARCIA, M. Mode of Infection of the Nervous System in Poliomyelitis of the Chick Embryo. Nature 178, 746–747 (1956). https://doi.org/10.1038/178746a0
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DOI: https://doi.org/10.1038/178746a0
