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Effect of Orotic Acid on Vitamin B12-deficient Rats

Nature volume 178, page 805 (1956)Cite this article

Abstract

STUDIES in this laboratory1,2 have recently shown that orotic acid is a factor for growth and survival in rats depleted of the animal protein factor of casein. Also, vitamin B12 has a protective effect on the deficiency in animal protein factor3. This indicates a relationship, from a nutritional point of view, between vitamin B12 and orotic acid. In the present communication the direct influence of orotic acid upon the deficiency of vitamin B12 is reported.

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References

  1. Viviani, R., Marchetti, M., Rabbi, A., and Moruzzi, G., Nature, 176, 464 (1955).

    Article  ADS  CAS  Google Scholar 

  2. Rabbi, A., Marchetti, M., Viviani, R., and Moruzzi, G., Nature, 177, 757 (1956).

    Article  ADS  CAS  Google Scholar 

  3. Rabbi, A., Viviani, R., and Marchetti, M., Int. Z. Vitaminf., 26, 185 (1955).

    CAS  Google Scholar 

  4. Register, U. D., Ruegamer, W. R., and Elvehjem, C. A., J. Biol. Chem., 177, 129 (1949).

    CAS  PubMed  Google Scholar 

  5. Williams, jun., J. N., Sreenivasan, A., Dietrich, L. S., Harper, A. E., and Elvehjem, C. A., J. Biol. Chem., 202, 151 (1953).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto di Chimica Biologica, Università di Bologna,

    M. MARCHETTI, R. VIVIANI & A. RABBI

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  1. M. MARCHETTI
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  2. R. VIVIANI
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  3. A. RABBI
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MARCHETTI, M., VIVIANI, R. & RABBI, A. Effect of Orotic Acid on Vitamin B12-deficient Rats. Nature 178, 805 (1956). https://doi.org/10.1038/178805a0

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