Abstract
A HUNDRED years have passed since Claude Bernard's publication of his investigations on the action of curarine in “Lecons sur les effets des substances toxiques et médicamenteuses”1. He was able by indirect experiments to localize the curare-block in the end-plates of skeletal muscle. Some time ago when we investigated the metabolism of carbon-14 – curarine I in the cat2, we tried to obtain auto-radiographs of muscle, intending to show the fixation of this alkaloid directly at the neuro-muscular junctions.
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References
Bernard, C., 238–353 (Paris, 1857).
Waser, P., Schmid, H., and Schmid, K., Archives Internat. de Pharmacodynamie et de Thérapie, 96, 386 (1954).
Koelle, G. B., and Friedenwald, J. S., Proc. Soc. Exp. Biol. and Med., 70, 617 (1949).
Couteaux, R., Thèse de l'université de Paris: “Contribution à l'étude de la synapse myoneurale” (Montréal, 1947).
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WASER, P., LÜTHI, U. Autoradiography of End-plates with Carbon-14 – Calabash – Curarine I and Carbon-14 – Decamethonium. Nature 178, 981 (1956). https://doi.org/10.1038/178981a0
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DOI: https://doi.org/10.1038/178981a0
