Abstract
IT has been demonstrated that the anti-epileptic drug, diphenylhydantoin (‘Phenytoin’), in rats is capable of inhibiting the pituitary–adrenal system, preventing the usual depletion of adrenal ascorbic acid by such stresses as unilateral adrenalectomy, intravenous vasopressin and subcutaneous epinephrine1
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BONNYCASTLE, D., PAASONEN, M. & GIARMAN, N. Diphenylhydantoin and Brain-Levels of 5-Hydroxytryptamine. Nature 178, 990–991 (1956). https://doi.org/10.1038/178990a0
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DOI: https://doi.org/10.1038/178990a0
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