Abstract
BUTLER1 has shown that the metabolism of 5 : 5-diphenylhydantoin in man leads to the excretion of what is presumed to be the pure lævorotatory form of 5-(p-hydroxyphenyl)-5-phenylhydantoin, melting point 326–328° (decomp.), [α]28 D − 16° (c. 0.4 in ethanol), through hydroxylation in one ring only. In dogs, however, hydroxylation of either of the two phenyl groups appears to proceed with almost equal facility: the excreted p-hydroxy derivative is slightly dextrorotatory.
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References
Butler, T. C., J. Pharmacol., 119, 1 (1957).
Gorvin, J. H., Nature, 161, 208 (1948).
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GORVIN, J., BROWNLEE, G. Metabolism of 5 : 5-Diphenylhydantoin in the Rabbit. Nature 179, 1248 (1957). https://doi.org/10.1038/1791248a0
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DOI: https://doi.org/10.1038/1791248a0
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