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Tranquillizing Drugs and Morphine-mania in Cats

Nature volume 179, page 1253 (1957)Cite this article

Abstract

CHLORPROMAZINE has been shown to potentiate morphine analgesia1–3, while reserpine antagonizes the analgesia2 as well as the central stimulatory action of morphine in the Straub tail reaction and in activity tests4 with mice. On the other hand, small doses of reserpine potentiate the mydriatic action of morphine in mice and large doses produce a meiosis characteristic of reserpine alone4. Since morphine produces a peculiar excitant or manic state in cats5, we were interested in the possible influences of these tranquillizing drugs on the morphine reaction in this species.

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Authors and Affiliations

  1. Division of Biological Research, G. D. Searle and Co., Chicago, 80, Ill.

    F. M. STURTEVANT & VICTOR A. DRILL

Authors
  1. F. M. STURTEVANT
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  2. VICTOR A. DRILL
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STURTEVANT, F., DRILL, V. Tranquillizing Drugs and Morphine-mania in Cats. Nature 179, 1253 (1957). https://doi.org/10.1038/1791253a0

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