Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

5-Hydroxytryptamine in Acute Inflammation

Nature volume 179, page 318 (1957)Cite this article

Abstract

IN the course of examining inflammatory exudate for substances capable of acting as mediators of increased capillary permeability it was found that in pleural exudates collected from rats within an hour of intrapleural injection of 0.1 ml. turpentine there were significant amounts of 5-hydroxytryptamine. Since then, similar exudate collected 30 min. after injury has been found to contain 1–3 µgm. 5-hydroxytryptamine/ml. One hour after injection this value has fallen to 0.2 µgm./ml. or less. 30-min. exudates contain less than 0.5 µgm. of histamine.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Spector, W. G., J. Path. Bact. (in course of publication).

  2. Spector, W. G., J. Path. Bct., 63, 93 (1951).

    Article  CAS  Google Scholar 

  3. Rowley, D. A., and Benditt, E. P., J. Exp. Med., 103, 399 (1956).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schneider, W. C., J. Biol. Chem., 176, 259 (1948).

    CAS  PubMed  Google Scholar 

  5. Miles, A. A., and Wilhelm, D. L., Brit. J. Exp. Path., 36, 71 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Armstrong, D., Dry, R. M. L., Keele, C. A., and Markham, J. W., J. Physiol., 120, 326 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Depts. of Morbid Anatomy and Medical Unit, University College Hospital Medical School, University Street, London, W.C.1

    W. G. SPECTOR & D. A. WILLOUGHBY

Authors
  1. W. G. SPECTOR
    View author publications

    Search author on:PubMed Google Scholar

  2. D. A. WILLOUGHBY
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SPECTOR, W., WILLOUGHBY, D. 5-Hydroxytryptamine in Acute Inflammation. Nature 179, 318 (1957). https://doi.org/10.1038/179318a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/179318a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing