A Case of Hæmoglobin J in an Indonesian Family

Abstract

SINCE the discovery of the abnormal human hæmoglobin H by Rigas et al. ¹, three other abnormal hæmoglobin types, I ², J ³ and K ⁴, have been found to migrate faster in paper electrophoresis than normal adult hæmoglobin at a pH. of 8.6. These four hæmoglobins can be distinguished by their differences in electrophoretic mobility at pH 8.6 (H = I<J<K<A), while the difference between hæmoglobin-H and hæmoglobin-I is demonstrable when they are compared on paper electrophoresis at pH 6.5².