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Plethysmometric Measurement of Swelling in the Feet of Small Laboratory Animals

Nature volume 179, page 629 (1957)Cite this article

Abstract

VARIOUS authors have described phlethysmometric1–3 and planimetric4–6 methods of measuring the volume of rats' and guinea pigs' feet before and after the injection of irritant substances. Such methods have formed the basis for the determination of the anti-inflammatory activity of adrenal steroids and other agents, and for the measurement of the local response to injections of histamine and histamine-releasing agents.

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References

  1. Domenjoz, R. D., Internat. Rec. Med., 165, 467 (1952).

    CAS  PubMed  Google Scholar 

  2. Wilhelmi, G., and Domenjoz, R. D., Arzneimittelforschung, 1, 151 (1951).

    CAS  PubMed  Google Scholar 

  3. Domenjoz, R. D., Schweiz. Med. Woch., 40, 1023 (1952).

    Google Scholar 

  4. Ungar, G., Damgaard, E., and Weinstein, H. G., Amer. J. Physiol., 166, 340 (1951).

    CAS  PubMed  Google Scholar 

  5. French, C. E., Allen, J. R., and Davis, K. J., Proc. Soc. Exp. Biol. and Med., 89, 41 (1955).

    Article  CAS  Google Scholar 

  6. Winter, C. A., Hollings, H. L., and Stebbins, R. B., Endocrinol., 52, 123 (1953).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmacy, University of London, 17 Bloomsbury Square, London, W.C.1

    G. A. H. BUTTLE, P. F. D'ARCY, E. M. HOWARD & D. N. KELLETT

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  1. G. A. H. BUTTLE
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  2. P. F. D'ARCY
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  3. E. M. HOWARD
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  4. D. N. KELLETT
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BUTTLE, G., D'ARCY, P., HOWARD, E. et al. Plethysmometric Measurement of Swelling in the Feet of Small Laboratory Animals. Nature 179, 629 (1957). https://doi.org/10.1038/179629a0

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