Abstract
CARNITINE (β-hydroxy-γ-butyrobetaine) stimulates the growth and the periosteal ossification of embryonic chick tibias and femurs cultivated in vitro 1,2 using the watch-glass technique3. This effect can be demonstrated if the embryo extract of the medium is diluted 20 or 200 times in Tyrode solution to get rid so far as possible of the natural carnitine always present in it (44–88 µgm./gm. dry weight for a 12-day-old chick embryo4). Measurements of the thickness of periosteal bone and counts of mitoses had indicated that the periosteum is a very sensitive site for the action of carnitine.
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LIÉBECQ-HUTTER, S., BACQ, Z. Antagonism of γ-Butyrobetaine and Carnitine on Chick Embryonic Bones cultivated in vitro . Nature 179, 871 (1957). https://doi.org/10.1038/179871a0
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DOI: https://doi.org/10.1038/179871a0
