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Phenols as Inhibitors of the Heparin Co-factor of Plasma

Abstract

PHENOLS counteract the antithrombic activity of plasma and serum1. The antithrombic activity is present in a protein fraction which also contains the co-factor required for the anticoagulant effect of heparin2. The antithrombic and the heparin co-factor activity are present in the α-globulin fraction of human plasma3. It was therefore of interest to test the influence of phenols on heparin activity in plasma.

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FANTL, P., MARR, A. Phenols as Inhibitors of the Heparin Co-factor of Plasma. Nature 180, 990 (1957). https://doi.org/10.1038/180990a0

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