Abstract
CYTOCHROME c-like compounds have been found to be proximate to rat kidney lysozyme in fractions derived from ion-exchange chromatography on ‘Amberlite IRC-50’ resin1. This led to experiments designed to test the effects of cytochrome c upon bacterial lysis by lysozyme. Although under certain conditions oxidized cytochrome c was found to increase the initial rate of lysis by lysozyme, the pigment alone had no antibacterial activity in vitro. In testing the potential activity of cytochrome in vivo, M. lysodeikticus was grown in the presence of lysozyme in very low concentrations (0.1 µgm./ml.) as a control. In this way the production of resistant cells was first observed.
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LITWACK, G. Development of Micrococcus lysodeikticus Resistant to Lysozyme. Nature 181, 1348–1350 (1958). https://doi.org/10.1038/1811348c0
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DOI: https://doi.org/10.1038/1811348c0
