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Assay of Erythropoietin in Bone Marrow Suspensions

Nature volume 181, pages 1537–1538 (1958)Cite this article

Abstract

RECENTLY the presence of a substance capable of stimulating erythropoiesis (erythropoietin) in the peripheral blood of man1 and anæmic animals2 has been demonstrated repeatedly by a variety of assay methods2–4. Except for the few techniques which utilize the normal animal for assay purposes, all the current methods employ animals altered in such a way as to increase sensitivity to the test substance. Despite theoretical objections raised to the use of non-physiological preparations, such as the hypo-physectomized or starved animal, in an assay, the results have been found reliable when iron-59 incorporation into the erythrocyte or reticulocytosis is chosen as the measure of erythropoietic activity5.

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References

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Authors and Affiliations

  1. National Cancer Institute and Argonne Cancer Research Hospital, and Department of Medicine, University of Chicago,

    LESLIE R. SCHROEDER

  2. Argonne Cancer Research Hospital, and Department of Medicine, University of Chicago,

    CLIFFORD W. GURNEY & NANCY WACKMAN

Authors
  1. LESLIE R. SCHROEDER
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  2. CLIFFORD W. GURNEY
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  3. NANCY WACKMAN
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SCHROEDER, L., GURNEY, C. & WACKMAN, N. Assay of Erythropoietin in Bone Marrow Suspensions. Nature 181, 1537–1538 (1958). https://doi.org/10.1038/1811537b0

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