Abstract
INVESTIGATIONS on the release of histamine slow-reacting substance from the perfused anaphylactic lung of the guinea pig reveal that cortisone is not inhibitory to the release of either substance. On the other hand, in as low a concentration as 1 in 140,000 the response of the guinea pig gut to histamine and slow-reacting substance is greatly reduced if the cortisone is left in contact with the gut for 1–3 min. Contact for 10 sec. is without significant effect so that assay of the output of histamine and slow-reacting substance is satisfactory on the isolated gut of the guinea pig. This effect, owing to the delay, may be due to intracellular action of cortisone on the effector organ.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TRETHEWIE, E. Anti-allergic Effect of Cortisone. Nature 181, 625 (1958). https://doi.org/10.1038/181625a0
Issue date:
DOI: https://doi.org/10.1038/181625a0
This article is cited by
-
Testosterone and Asthma
Nature (1963)
