Abstract
THE synthesis of new cytostatic drugs is governed by the attempt to find new substances which unite maximum therapeutic effectiveness with minimum toxicity. For this purpose it seems to be advantageous not to apply the substance in its active form, but by introducing suitable chemical groups to transform it into an inert transport substance which will be reconverted into the active form at the site of therapeutic action in the body. This principle has already proved of value in the treatment of prostatic carcinoma with stilbœstrol diphosphate1.
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References
Druckrey, H., and Raabe, S., Klin. Wschr., 30, 882 (1952).
Friedman, O. M., and Seligman, A. M., J. Amer. Chem. Soc., 76, 655 (1954).
Druckrey, H., Schmähl, D., Danneberg, P., Kaiser, K., Nieper, H. A., Lo, H. W., and Mecke, R., Arzneim.-Forsch., 6, 539 (1956).
Arnold, H., and Bourseaux, F., Angew. Chemie (1958). Arnold, H., Bourseaux, F., and Brock, N., Naturwiss., 45, 64 (1958). Brock, N., Arzneim.-Forsch., 8, 1 (1958). Brock, N., and Wilmanns, H., Deutsch. med. Wschr., 83, 463 (1958).
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ARNOLD, H., BOURSEAUX, F. & BROCK, N. Chemotherapeutic Action of a Cyclic Nitrogen Mustard Phosphamide Ester (B 518-ASTA) in Experimental Tumours of the Rat. Nature 181, 931 (1958). https://doi.org/10.1038/181931a0
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DOI: https://doi.org/10.1038/181931a0
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