Abstract
Layne and Marrian1 recently reported the isolation of 16β-hydroxyœstrone from the urine of pregnant women, and Brown, Fishman and Gallagher2 detected the same compound by reverse isotope dilution in the urine of a human subject after the administration of œstradiol-17β-1614-C. In the course of our own studies on the metabolism of œstrogens in vitro, 16β-hydroxyœstrone has been found after incubation of 16-oxoœstrone with normal human liver slices. In addition, five other phenolic steroids have been identified as metabolites of 16-oxoœstrone.
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References
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BREUER, H., KNUPPEN, R. Metabolism of 16-Oxoœstrone by Human Liver Slices in vitro . Nature 182, 1512 (1958). https://doi.org/10.1038/1821512a0
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DOI: https://doi.org/10.1038/1821512a0
