Abstract
METABOLIC activity is profoundly altered in the hibernating animal, as compared with that in the normal. Evidence is also available that under hibernating conditions nervous function in certain species can be affected1. Consequently it was of considerable interest to determine the toxicity of a ganglionic blocking agent to animals under the abnormal metabolic conditions produced by hibernation. The toxicity of the cholinesterase inhibitor O, O-diethyl-S-2- diethylaminoethyl phosphonothiolate2 has been determined in the nornal and hibernating hamster by the intraperitoneal route.
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References
Kayser, C., Année Biologique, 29, 109 (1953).
Ghosh, R., and Newman, J. F., Chem. and Indust., 118 (1955).
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SCAIFE, J., CAMPBELL, D. Toxicity of a Cholinesterase Inhibitor to the Hibernating Hamster. Nature 182, 1739 (1958). https://doi.org/10.1038/1821739a0
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DOI: https://doi.org/10.1038/1821739a0
