Abstract
IT has been suggested that the hyperglycæmic substance present in the blood of the pancreaticoduodenal vein of animals treated with the growth hormone of the pituitary gland is 5-hydroxytryptamine1. This amine may be derived from the enterochromaffin or other cells of the gastrointestinal tract. Yet injections of 5-hydroxytryptamine into normal dogs fail to produce a significant rise in blood sugar, although similar injections into depancreatized animals result in hyperglycæmia. Thus the pancreas may be responsible for the inactivation of 5-hydroxytryptamine.
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References
Sirek, A., Nature, 179, 376 (1955).
Gaddum, J. H., and Giarman, N. J., Brit. J. Pharmacol., 11, 88 (1956).
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WEST, G. 5-Hydroxytryptamine and Hyperglycæmia. Nature 182, 182 (1958). https://doi.org/10.1038/182182a0
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DOI: https://doi.org/10.1038/182182a0
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