Abstract
GLUTAMIC ACID and its esters and salts have a tendency to form α-pyrrolidone derivatives1 by lactam formation: 
The cyclization can be brought about by heating. A strong catalytic effect of ammonia has been recorded2.
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HUBERT, A., BUIJLE, R. & HARGITAY, B. Carbon Dioxide Catalysis of the Formation of Pyroglutamic Acid. Nature 182, 259 (1958). https://doi.org/10.1038/182259a0
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DOI: https://doi.org/10.1038/182259a0
