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Gamma-Amino-n-Butyric Acid and Spinal Synaptic Transmission

Abstract

A MAJOR constituent of factor I isolated from mammalian brain has been shown to be γ-amino-n-butyric acid1. It has been assumed that this material, an inhibitor of the crayfish stretch receptor, is an inhibitory transmitter substance within the mammalian central nervous system2. Recent investigations indeed have shown that γ-amino-n-butyric acid reversibly depresses the potentials arising from the synaptic activation of cells within the cerebral cortex3 but no precise differentiation as to the mode of action of γ-amino-n-butyric acid has been attempted.

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References

  1. Bazemore, A., Elliott, K. A. C., and Florey, E., Nature, 178, 1052 (1956).

    Article  ADS  CAS  Google Scholar 

  2. Florey, E., and McLennan, H., J. Physiol., 130, 446 (1955).

    Article  CAS  Google Scholar 

  3. Iwama, I., and Jasper, H. H., J. Physiol., 138, 365 (1957). Purpura, D. P., Guado, M., and Grundfest, H., Science, 125, 1200 (1957). Marrazzi, A. S., Hart, E. R., and Rodriguez, J. M., Science, 127, 284 (1958).

    Article  CAS  Google Scholar 

  4. Eccles, J. C., “The Physiology of Nerve Cells” (Johns Hopkins Press, 1957).

    Google Scholar 

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CURTIS, D., PHILLIS, J. Gamma-Amino-n-Butyric Acid and Spinal Synaptic Transmission. Nature 182, 323 (1958). https://doi.org/10.1038/182323a0

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