Abstract
THE discrepancy between our results and those of Kritchevsky and Moyer could be explained as follows : (a) In comparison with the dosages used by Kritchevsky and Moyer, our rabbits were given a smaller total amount of cholesterol and a greater total amount of α-lipoic acid, with a ratio between cholesterol and α-lipoic acid comparatively in favour of the latter in unit time. (b) That there is a critical value in the α-lipoic acid dosage for the ‘anticholesterol properties’ can be argued from the fact that in humans with high serum cholesterol-levels, chronic treatment with α-lipoic acid 25 mgm. twice a day did not change the serum cholesterol-levels, whereas 50 mgm. once a day gave a moderate decrease in the serum cholesterol levels (Consolo et al., Boll. Soc. Ital. Biol. Sper., 32, 1325 ; 1957).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ANGELUCCI, L., MASCITELLI-CORIANDOLI, E. Anticholesterol Activity of α-Lipoic Acid. Nature 182, 396 (1958). https://doi.org/10.1038/182396b0
Issue date:
DOI: https://doi.org/10.1038/182396b0