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Anticholesterol Activity of α-Lipoic Acid

Abstract

THE discrepancy between our results and those of Kritchevsky and Moyer could be explained as follows : (a) In comparison with the dosages used by Kritchevsky and Moyer, our rabbits were given a smaller total amount of cholesterol and a greater total amount of α-lipoic acid, with a ratio between cholesterol and α-lipoic acid comparatively in favour of the latter in unit time. (b) That there is a critical value in the α-lipoic acid dosage for the ‘anticholesterol properties’ can be argued from the fact that in humans with high serum cholesterol-levels, chronic treatment with α-lipoic acid 25 mgm. twice a day did not change the serum cholesterol-levels, whereas 50 mgm. once a day gave a moderate decrease in the serum cholesterol levels (Consolo et al., Boll. Soc. Ital. Biol. Sper., 32, 1325 ; 1957).

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ANGELUCCI, L., MASCITELLI-CORIANDOLI, E. Anticholesterol Activity of α-Lipoic Acid. Nature 182, 396 (1958). https://doi.org/10.1038/182396b0

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