Abstract
PARTICULATE matter and cells injected sub-cutaneously are normally localized at the site of injection, while the suspending medium diffuses outwards1. Exceptional behaviour might be expected of cells from the bone marrow and spleen, however, for these cells can become established in homologous tissues after intravenous injection into irradiated hosts2. On the other hand, the intravenous route of injection is more effective than the subcutaneous in procuring the functional survival of these cells, as judged by protection against lethal irradiation3, and the adoptive transfer of immunity4. The continued production of a specific antibody by spleen cells was used in the present experiments, to determine their localization after subcutaneous implantation.
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HAŠKOVÁ, V., MITCHISON, N. Migration of Spleen Cells from Subcutaneous Implantation Sites. Nature 182, 410 (1958). https://doi.org/10.1038/182410a0
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DOI: https://doi.org/10.1038/182410a0
