Abstract
MOST methods used for the estimation of strychnine in nux vomica lead to gross inaccuracies due to brucine interference. Even oxidation of brucine with nitric acid under optimal condition (5 min. at 60° C.) leads to errors due to partial destruction of strychnine1. Gravimetric estimations also require amounts greater than 0.1 gm. in the sample1.
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References
de la Vega, F. A., and Del Pozo, A., Galenica Acta (Madrid), 2, 35 (1949), cited in Chem. Abstr., 47, 9571b (1953).
Dušinský, G., and Tyllová, M., Nature, 181, 1335 (1958).
Kay, S., and Hoff, E. C., J. Criminal Law, Criminol. Police Sci., 43, 264 (1953), cited in Chem. Abstr., 48, 6325e (1954).
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BRINER, G. Determination of Strychnine in Nux Vomica by Paper Chromatography. Nature 182, 742 (1958). https://doi.org/10.1038/182742a0
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DOI: https://doi.org/10.1038/182742a0
