Abstract
AFTER consultation with Holman, his experiment1 was repeated as closely as possible in all details, except the strain of rat used, which was an inbred strain of Wistar origin. Experimental animals and controls carried tumours of the 9th, 10th, 11th and 15th successive transplants into this strain of a Walker carcinoma obtained from the Chester Beatty Research Institute. On the sixth day after inoculation, the drinking water of experimental animals was replaced by 0.45 per cent hydrogen peroxide in tap water. Tumours in experimental animals then ranged from 3.5 to 5.4 cm. longest diameter (mean 4.46 cm.), and in controls from 3.0 to 5.6 cm. (mean 4.48 cm.).
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References
Holman, R. A., Nature, 179, 1033 (1957).
Miller, H., Biochem. J., 68, 275 (1958).
Ghadially, F. N., and Wiseman, G., Nature, 181, 1067 (1958).
Chora̧žy, M., Gettlich, A., Góral, L., Koloczek, B., Molawka, E., Penar, B., and Szweda, Z., Nature, 182, 395 (1958).
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JEFFREE, G. Hydrogen Peroxide and Cancer. Nature 182, 892 (1958). https://doi.org/10.1038/182892a0
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DOI: https://doi.org/10.1038/182892a0
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