Abstract
WHILE studying the therapeutic effect of homologous bone marrow transplantation in irradiated mice we needed a simple and sensitive technique to differentiate between the hæmatopoietic activity of the host and that of the graft. The possibility of employing differences between the hæmoglobins of our two strains of mice (CBA and C57BL) and their hybrid was suggested by the findings of Ranney et al. 1,2, who demonstrated two different hæmoglobin patterns in eight inbred strains of mice by using paper electrophoresis.
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References
Ranney, H. M., and Gluecksohn-Waelsch, S., Ann. Hum. Genetics, 19, 269 (1955).
Gluecksohn-Waelsch, S., Ranney, H. M., and Sisken, B. F., J. Clin. Invest., 36, 753 (1957).
Robinson, A. R., Robson, M., Harrison, A. P., and Zuelzer, W. W., J. Lab. Clin. Med., 50, 745 (1957).
Jonxis, J. H. P., and Visser, H. K. A., Amer. J. Diseases of Children, 92, 588 (1956).
Itano, H. A., Fed. Proc., 16, 748 (1957).
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WELLING, W., VAN BEKKUM, D. Different Types of Hæmoglobin in Two Strains of Mice. Nature 182, 946–947 (1958). https://doi.org/10.1038/182946b0
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DOI: https://doi.org/10.1038/182946b0
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