Abstract
ULTRACENTRIFUGAL analysis has shown that one of the main ribonucleoprotein components of bacterial cytoplasm is sensitive to alterations in the concentrations of certain salts present in the growth medium, or in the medium in which cells are suspended before they are disrupted1–3. This component sediments at about 40S. (uncorrected) and its breakdown within whole cells is favoured by lowering the concentration of magnesium ions or raising that of inorganic phosphate; ribonucleoprotein particles sedimenting at about 29 and 20S. are relatively insensitive to these extracellular changes in concentration.
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References
Dagley, S., and Skyes, J., Nature, 179, 1249 (1957).
Dagley, S., and Sykes, J., “Microsomal Particles and Protein Synthesis”, 62 (Pergamon Press, London, 1958).
Bowen, T. J., Dagley, S., and Sykes, J., Biochem. J., 71, 14P (1959).
Bowen, T. J., Dagley, S., and Sykes, J., Biochem. J. (in the press).
Hughes, D. E., Brit. J. Exp. Path., 32, 97 (1951).
Neidhardt, F. C., and Gros, F., Biochim. Biophys. Acta, 25, 513 (1957).
Hahn, F. E., Schaechter, M., Ceglowski, W. S., Hopps, H. E., and Ciak, J., Biochim. Biophys. Acta, 26, 469 (1957).
Pardee, A. B., Paigen, K., and Prestidge, L. S., Biochim. Biophys. Acta, 23, 162 (1957).
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DAGLEY, S., SYKES, J. Effect of Drugs upon Components of Bacterial Cytoplasm. Nature 183, 1608–1609 (1959). https://doi.org/10.1038/1831608a0
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DOI: https://doi.org/10.1038/1831608a0
