Abstract
THE pathological changes in the muscle in human muscular dystrophy have been well characterized. They consist of great diversity of muscle fibre size, increase in number of sarcolemmal nuclei (which may take the form of chains situated centrally in the fibre), and atrophy of the fibres. Although it has been said1 that phagocytosis of degenerating fibres is rare, we have found evidence in a number of cases of what appears to be invasion and destruction of muscle fibres by elements of connective tissue.
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References
Adams, R. D., Denny-Brown, D., and Pearson, C. M., “Diseases of Muscle”, 259 (Paul B. Hoeber, 1954).
Beckett, E. B., and Bourne, G. H., J. Neuropath. Exp. Neurol., 17, 2, 199 (1958).
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BOURNE, G., GOLARZ, M. Human Muscular Dystrophy as an Aberration of the Connective Tissue. Nature 183, 1741–1743 (1959). https://doi.org/10.1038/1831741a0
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DOI: https://doi.org/10.1038/1831741a0
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