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Life-Span of Rat and Mouse Erythrocytes in the Rat–Mouse Chimera

Abstract

THE secondary disease observed in irradiated animals treated with foreign bone marrow is of general interest and importance. The basic question which remains unanswered is whether immunologically competent cells in the chimera originate from the donor, the host, or a combination of both. Erythrocyte life-span studies might be expected to throw light on whether this secondary reaction, in so far as it is reflected in red cell survival, is of host or of donor origin.

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GOODMAN, J., SMITH, L. Life-Span of Rat and Mouse Erythrocytes in the Rat–Mouse Chimera. Nature 183, 1833 (1959). https://doi.org/10.1038/1831833a0

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