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Effect of Salicylate on Blood and Liver Xanthine Dehydrogenase of Rats

Abstract

MILK and liver xanthine oxidase are inhibited by sodium salicylate in vitro 1. Bergel et al. 2 were able to utilize this property for the stabilization of xanthine oxidase by adding salicylate to the process of purification of the enzyme.

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References

  1. Lutwak-Mann, C., Biochem. J., 36, 706 (1942).

    Article  CAS  Google Scholar 

  2. Bergel, F., and Bray, R. C., Nature, 178, 88 (1956).

    Article  ADS  CAS  Google Scholar 

  3. Affonso, O. R., Mitidieri, E., Ribeiro, L. P., and Villela, G. G., Proc. Soc. Exp. Biol. Med., 90, 527 (1955).

    Article  CAS  Google Scholar 

  4. Drill, V. A., “Pharmacology in Medicine” (McGraw-Hill Book Co., Inc., 1958).

    Google Scholar 

  5. Bruns, F., and Neuhaus, J., Arch. Biochem. Biophys., 55, 588 (1955).

    Article  CAS  Google Scholar 

  6. Villela, G. G., Mitidieri, E., and Affonso, O. R., Nature, 175, 1087 (1956).

    Article  ADS  Google Scholar 

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MITIDIERI, E., AFFONSO, O. Effect of Salicylate on Blood and Liver Xanthine Dehydrogenase of Rats. Nature 183, 471 (1959). https://doi.org/10.1038/183471a0

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