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Role of Lysine in catalysing Ester Hydrolysis

Abstract

RECENTLY, Gero and Withrow1 have cited the catalysis of alkaline triglyceride hydrolysis by lysine as a chemical model of a biological reaction. They postulated a bifunctional2 attack by lysine upon the carbonyl O and C of the ester linkage as the mechanism of this hydrolysis.

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References

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CHESBRO, W., HEDRICK, L. Role of Lysine in catalysing Ester Hydrolysis. Nature 183, 994 (1959). https://doi.org/10.1038/183994a0

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