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Chromatographic Fractionation of Rat Tail Tendon Collagen

Nature volume 184, page 1640 (1959)Cite this article

Abstract

PHYSICAL studies1 indicate that solubilized collagens give rise to two components when heated gently (13°–40° C. depending on the source of the collagen)2 or when treated with other agents which break weak bonds. These two components have not been satisfactorily isolated3 by the methods used to fractionate4 ‘gelatine’, an end-product of more drastically altered collagen. We have succeeded in chromatographing warm dissolved rat tail tendon collagen into four components with a method which allows for the isolation of these components.

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References

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Authors and Affiliations

  1. Department of Surgical Metabolism and Physiology, Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, 12, D.C.

    ALEXANDER KESSLER, HYMAN ROSEN & STANLEY M. LEVENSON

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  1. ALEXANDER KESSLER
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  2. HYMAN ROSEN
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  3. STANLEY M. LEVENSON
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KESSLER, A., ROSEN, H. & LEVENSON, S. Chromatographic Fractionation of Rat Tail Tendon Collagen. Nature 184, 1640 (1959). https://doi.org/10.1038/1841640a0

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