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Presence of 5-Hydroxytryptamine after Raunescine in Blood Plasma in vivo

Nature volume 185, page 109 (1960)Cite this article

Abstract

5-HYDROXYTRYPTAMINE is localized in the platelets of the blood, minimal amounts being found in platelet-free plasma1–3. Rauwolfia alkaloids are known to lower the content of 5-hydroxytryptamine in various tissues including blood both in vivo, and in vitro 4,5. Whether 5-hydroxytryptamine is released by Rauwolfia alkaloids from the cellular binding sites as such to the cytoplasma is still not clear. It has been stated that the incubation of rabbit platelet suspensions with reserpine in an atmosphere of nitrogen increases the amount of 5-hydroxytryptamine in plasma5.

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Authors and Affiliations

  1. Department of Pharmacology, University of Helsinki, Finland

    N. T. KÄRKI & M. K. PAASONEN

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  1. N. T. KÄRKI
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  2. M. K. PAASONEN
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KÄRKI, N., PAASONEN, M. Presence of 5-Hydroxytryptamine after Raunescine in Blood Plasma in vivo . Nature 185, 109 (1960). https://doi.org/10.1038/185109a0

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