Abstract
THE sera of the guinea pig1,2, rat3, rabbit3and man4contain the inactive precursor (pro-PF) of a globulin permeability factor (PF) activable by dilution in saline (PF/Dil) or by chemical fractionation. The in vivomechanism of activation is unknown; but an obvious hypothesis—that activation in injury is induced by contact of the pro-PFwith damaged tissue—was investigated by testing the effect on guinea pig serum of debris from homogenates of guinea pig tissues.
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MILL, P. Induction of a Vascular Permeability Factor by the Interaction of Guinea Pig Tissue Debris with Serum. Nature 185, 246–247 (1960). https://doi.org/10.1038/185246a0
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DOI: https://doi.org/10.1038/185246a0
