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Suppression of Increased Capillary Permeability in Injury by Monoamine Oxidase Inhibitors

Nature volume 186, pages 162–163 (1960)Cite this article

Abstract

PREVIOUS work has indicated that many of the vascular phenomena of inflammation (especially vasodilation and increased capillary permeability) may be attributed to the local release or activation of compounds with the appropriate pharmacological properties, for example, histamine, peptides or globulins1–5. A possibility that has received little or no attention is that injury may lead to the local destruction of vasoconstrictor compounds, thus enhancing the effect of released vasodilators.

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References

  1. Spector, W. G., and Willoughby, D. A., Nature, 181, 708 (1958).

    Article  ADS  CAS  Google Scholar 

  2. Spector, W. G., and Willoughby, D. A., Nature, 182, 949 (1958).

    Article  ADS  CAS  Google Scholar 

  3. Spector, W. G., Pharmacol. Rev., 10, 475 (1958).

    CAS  PubMed  Google Scholar 

  4. Wilhelm, D. L., J. Physiol., 148, 9, P (1959).

    Google Scholar 

  5. Menkin, V., “Biochemical Mechanism in Inflammation”, 2nd ed. (Thomas, Springfield, Illinois, 1956).

    Google Scholar 

  6. Parratt, J. R., and West, G. B., Brit. J. Pharmacol., 13, 65 (1958).

    CAS  PubMed  Google Scholar 

  7. Axelrod, J., Physiol. Rev., 39, 751 (1959).

    Article  CAS  Google Scholar 

  8. Spector, W. G., and Willoughby, D., J. Path. Bact., 77, 1 (1959).

    Article  CAS  Google Scholar 

  9. Spector, W. G., and Willoughby, D. A., J. Path. Bact., 78, 121 (1959).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Morbid Anatomy and Medical Unit, University College Hospital Medical School, London

    W. G. SPECTOR & D. A. WILLOUGHBY

Authors
  1. W. G. SPECTOR
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  2. D. A. WILLOUGHBY
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SPECTOR, W., WILLOUGHBY, D. Suppression of Increased Capillary Permeability in Injury by Monoamine Oxidase Inhibitors. Nature 186, 162–163 (1960). https://doi.org/10.1038/186162a0

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