Abstract
THE base analogues, 5-bromouracil and 2-aminopurine, employed by Freese1 to study the rII region of the genetic material of bacteriophage T4 were also found to induce reversions from auxotrophy to prototrophy in Salmonella typhimurium. It was determined that 5-bromouracil can be incorporated into the deoxyribonucleic acid of this organism, replacing thymine specifically.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Freese, E., Proc. U.S. Nat. Acad. Sci., 45, 622 (1959).
Demerec, M., Lahr, E. E., Balbinder, E., Miyake, T., Mack, C., Mackay, D., and Ishidsu, J., Carnegie Inst. Wash. Year Book, 58 (1959).
Zamenhof, S., et al., J. Biol. Chem., 219, 165 (1956).
Freese, E., J. Mol. Biol., 1, 87 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RUDNER, R., BALBINDER, E. Reversions induced by Base Analogues in Salmonella typhimurium . Nature 186, 180 (1960). https://doi.org/10.1038/186180a0
Issue date:
DOI: https://doi.org/10.1038/186180a0
This article is cited by
-
Induction of reverse mutations in a thymine-dependent strain of Escherichia coli and study of donor ability of the revertants
Bulletin of Experimental Biology and Medicine (1968)
-
Effect of Ultra-violet Light on Tobacco Mosaic Virus containing 5-Fluorouracil
Nature (1963)
-
Effects of Incorporation of Iododeoxyuridine on Escherichia coli
Nature (1963)
-
Mutation as an error in base pairing
Zeitschrift f�r Vererbungslehre (1961)
-
The effects of deuterium oxide on bacteria
Zeitschrift f�r Vererbungslehre (1961)
