Abstract
ABNORMALLY high rates of excretion of 4-hydroxy-3-methoxymandelic acid, a metabolite of both adrenaline and noradrenaline, are now well known to be associated with phaeochromocytoma and sympathoblastoma1–3. A convenient chromatographic technique enabling the substance to be estimated visually has been described elsewhere3. It seemed of interest to examine the possibility that the method would prove sufficiently sensitive to detect the increased secretions of the catecholamines to be anticipated in subjects exposed to stress.
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Armstrong, M. D., and McMillan, A., Fed. Proc., 16, 146 (1957).
Sandler, M., and Ruthven, C. J. R., Lancet, ii, 114 (1959).
Robinson, R., Ratcliffe, J., and Smith, P., J. Clin. Path. (in the press).
Shaw, K. N. F., McMillan, A., and Armstrong, M. D., J. Biol. Chem., 226, 255 (1957).
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ROBINSON, R., SMITH, P. Urinary Phenols in Stress. Nature 186, 240 (1960). https://doi.org/10.1038/186240a0
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DOI: https://doi.org/10.1038/186240a0
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