Abstract
IT was shown in a recent paper1 that the zinc content of whole blood in cases of very different cancers was subnormal (a mean decrease of about 20 per cent being found). Various metalloproteins are known which contain zinc as an essential part2. It seems wise to devote careful attention to carbonic anhydrase, a substance present in relatively large amounts in red blood corpuscles and described in detail by Keilin and Mann3.
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References
Addink, N. W. H., and Frank, L. J. P., Cancer, 12, 544 (1959).
Vallee, B. L., “Adv. Protein Chem.”, 10, 317 (Academic Press, New York, 1955).
Keilin, D., and Mann, T., Biochem. J., 34, 1163 (1940).
Addink, N. W. H., Rec. Trav. Chim. Pays-Bas., 74, 197 (1955).
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Bate-Smith, E. C., Biochem. J., 34, 1176 (1940).
Greenstein, J. P., “Biochemistry of Cancer”, 450 (Academic Press, New York, 1954).
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ADDINK, N. Subnormal Level of Carbonic Anhydrase in Blood of Carcinoma Patients?. Nature 186, 253 (1960). https://doi.org/10.1038/186253a0
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DOI: https://doi.org/10.1038/186253a0
