Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A Connexion between S—S Bond Breakage and Inactivation by Radiation of a Dry Enzyme

Nature volume 186, pages 312–313 (1960)Cite this article

Abstract

IT has previously been established that the inactivation of a dry enzyme by ionizing radiation requires an ionization either within the enzyme molecule or very close to it1. It is known that the radiosensitivity can be varied by a factor of the order of magnitude of 2 by temperature2, oxygen tension3, and materials which surround the enzyme molecule in the dry state4. The mechanism for the inactivation is unknown.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pollard, E. C., Guild, W. R., Hutchinson, F., and Setlow, R. B., “Prog. in Biophys.”, 5, 72 (1955).

    CAS  Google Scholar 

  2. Pollard, E. C., Powell, W., and Reaume, S. H., Proc. U.S. Nat. Acad. Sci., 38, 173 (1952).

    Article  ADS  CAS  Google Scholar 

  3. Alexander, P., Rod. Res., 6, 653 (1957).

    Article  CAS  Google Scholar 

  4. Braams, R., Hutchinson, F., and Ray, D., Nature, 182, 1506 (1958).

    Article  ADS  CAS  Google Scholar 

  5. Hirs, C. H. W., J. Biol. Chem., 219, 611 (1956).

    CAS  PubMed  Google Scholar 

  6. Sela, M., White, jun., F. H., and Anfinsen, C. B., Biochim. Biophys. Acta, 31, 417 (1959).

    Article  CAS  Google Scholar 

  7. Alexander, P., Hamilton, L. D. G., and Stacey, K. A., Nature, 184, 226 (1959).

    Article  ADS  CAS  Google Scholar 

  8. Gordy, W. R., Ard, W. B., and Shields, H., Proc. U.S. Nat. Acad. Sci., 41, 983 (1955).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biophysics Department, Yale University, New Haven, Conn.

    DILIP K. RAY, FRANKLIN HUTCHINSON & H. J. MOROWITZ

Authors
  1. DILIP K. RAY
    View author publications

    Search author on:PubMed Google Scholar

  2. FRANKLIN HUTCHINSON
    View author publications

    Search author on:PubMed Google Scholar

  3. H. J. MOROWITZ
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RAY, D., HUTCHINSON, F. & MOROWITZ, H. A Connexion between S—S Bond Breakage and Inactivation by Radiation of a Dry Enzyme. Nature 186, 312–313 (1960). https://doi.org/10.1038/186312b0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/186312b0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing