Abstract
THE observation by Aiyar et al. 1 that thyrotoxicosis in the rat is accompanied by an increase in liver ubiquinone prompts us to record our own related findings. We have investigated the effect of thyroxine and 2,4-dinitrophenol on both ubiquinone and ubichromenol-levels in the rat, using animals from a stock colony and also from a vitamin-E deficient colony. Female rats were used, aged 3–4 months in one experiment and aged 15 months in another. The animals were divided into groups of six, and test groups received thyroxine, thyroxine and α-tocopheryl acetate, or 2,4-dinitrophenol. After three weeks on test, the rats were killed, and their hearts and livers (each organ pooled with others from the same group) were analysed for ubiquinone and ubichromenol by the method of Diplock et al. 2. The results are given in Table 1, the figures for ubiquinone and ubichromenol representing the total isoprenologue content3 in each case.
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References
Aiyar, A. S., Sulebele, G. A., Rege, D. V., and Sreenivasan, A., Nature, 184, 1867 (1959).
Diplock, A. T., Green, J., Edwin, E. E., and Bunyan, J., Biochem. J. (in the press).
Diplock, A. T., Edwin, E. E., Green, J., Bunyan, J., and Marcinkiewicz, S., Nature, 186, 554 (1960).
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EDWIN, E., GREEN, J., DIPLOCK, A. et al. Effect of Thyroxine and 2,4-Dinitrophenol on Levels of Ubiquinone and Ubichromenol in the Rat. Nature 186, 725 (1960). https://doi.org/10.1038/186725a0
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DOI: https://doi.org/10.1038/186725a0
