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Concentration-Dependent Sedimentation of Aggregating Proteins in the Ultracentrifuge

Nature volume 186, pages 882–883 (1960)Cite this article

Abstract

PROTEINS are by nature sticky substances, and it is not surprising that many of them form molecular aggregates in solution at well below the concentration needed for the appearance of a stable solid phase. Ultracentrifuge measurements provide a direct method of detecting and estimating such aggregation, and this communication is concerned with the interpretation of these measurements when aggregation is rapidly reversible, and the velocity of each sedimenting species is a function of the total concentration of protein.

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Authors and Affiliations

  1. Department of Chemistry, The University, Edgbaston, Birmingham, 15

    G. A. GILBERT

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  1. G. A. GILBERT
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GILBERT, G. Concentration-Dependent Sedimentation of Aggregating Proteins in the Ultracentrifuge. Nature 186, 882–883 (1960). https://doi.org/10.1038/186882a0

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