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Labilization of Deoxyribonucleic Acid in Thymus Nucleoprotein after Whole-body Irradiation

Abstract

THE effect of total-body irradiation on the nucleo-protein in the sensitive organs can be demonstrated by a decrease of the viscosity1. Besides this, it has been shown that there is also a “labilisation of deoxyribonucleoprotein-moiety”2 after a total-body irradiation and probably “the chromosome breaks may originate mainly in the junction of DNA particles with histone”3. To explain the effect of irradiation on nucleoproteins, it is probably necessary to study in more detail the binding between the deoxyribonucleic acid and the protein before and after irradiation.

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HAGEN, U. Labilization of Deoxyribonucleic Acid in Thymus Nucleoprotein after Whole-body Irradiation. Nature 187, 1123–1124 (1960). https://doi.org/10.1038/1871123a0

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