Absence of Local Cytotoxic Change in Man from Griseofulvin

Abstract

WITH the importance of griseofulvin in the treatment of superficial fungous infections, it is imperative to know more about the toxic reactions especially if treatment is prolonged. Since the significant studies of Paget and Walpole¹ on the interference with mitosis under massive parenteral administration of griseofulvin in rats, there has been continued interest in investigations of this phase of reaction in man. Our purpose was to develop a technique for studying possible local cytotoxic reactions in man from locally deposited griseofulvin.