Abstract
IN an effort to clarify the role of abnormal creatine metabolism in producing muscular dystrophy a search for an antimetabolite to creatine has been made. If a specific defect in either the synthesis or utilization of creatine could be produced by an antimetabolite, it would then be possible to assess the change in muscle structure and metabolism which results from impaired creatine metabolism.
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References
Bengelsdorf, I. S., J. Amer. Chem. Soc., 75, 3138 (1953).
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FITCH, C., DINNING, J. Production of Muscular Weakness in Rats by a Creatine Analogue. Nature 187, 421 (1960). https://doi.org/10.1038/187421a0
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DOI: https://doi.org/10.1038/187421a0
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