Abstract
IT has been shown1–5 that chronic administration of deoxycorticosterone acetate decreases brain excitability and potentiates anticonvulsant drugs, and that this effect is correlated with increased plasma and decreased brain intracellular sodium concentrations. In contrast, adrenal insufficiency produces the opposite effects2. Similarly, deoxycorticosterone acetate is known to be a relatively potent anæsthetic steroid6.
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STURTEVANT, F. Electro-shock Seizure Threshold of Metacorticoid Hypertensive Rats. Nature 187, 874 (1960). https://doi.org/10.1038/187874a0
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DOI: https://doi.org/10.1038/187874a0
