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Synthesis of Nicotinic Acid Nucleotides

Abstract

NICOTINIC acid nucleotide (5′-phospho-β-D-ribofuranosylpyridinium-3-carboxylate) and its adenylyl derivative, adenine-nicotinic acid dinucleotide, have recently been identified as intermediates in the biosynthesis of pyridine nucleotide coenzymes1. These compounds have been found in fungi2,3, and the mononucleotide has been isolated in small amounts from yeast4. Both nucleotides have also been obtained in very low yields by enzymic modification of adenine-nicotinamide dinucleotide (coenzyme I)2,3,5.

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ATKINSON, M., MORTON, R. Synthesis of Nicotinic Acid Nucleotides. Nature 188, 58 (1960). https://doi.org/10.1038/188058b0

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