Abstract
ACTIVE transport of sodium across cell membranes is now established as one of the fundamental physiological processes of most vertebrate cells. This process probably requires some sort of carrier molecule which binds sodium and which is coupled to a source of energy, the whole being designated for simplicity as a ‘pump’. Failure of sodium transport may occur because of failure of energy supply, as, for example, in ischæmic skin and muscle after injury1. Certain drugs, such as cardiac glycosides, inhibit active transport by competing with sodium for the carrier2. One might also expect to find instances of failure or abnormalities of the pump itself, particularly in disease, but no examples of this are known.
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FUHRMAN, G., FUHRMAN, F. Inhibition of Active Sodium Transport by Cholera Toxin. Nature 188, 71–72 (1960). https://doi.org/10.1038/188071a0
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DOI: https://doi.org/10.1038/188071a0
