Abstract
PREVIOUSLY1 we reported the reduction reaction of α-aminoadipic acid by a yeast enzyme(s) which will now be referred to tentatively as α-aminoadipic acid reductase. The reaction by which α-aminoadipic acid is converted to the corresponding δ-semialdehyde requires the participation of adenosine triphosphate, reduced triphosphopyridine nucleotide and Mg++, and the enzyme is activated by glutathione. The present communication reports the formation of δ-adenyl-α-aminoadipic acid by the α-aminoadipisc acid reductase, together with a possible mechanism of α-aminoadipic acid reduction reaction.
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References
Sagisaka, S., and Shimura, K., Nature, 184, 1709 (1959).
Kornberg, A., and Pricer, jun., W. E., J. Biol. Chem., 189, 123 (1951).
Hoagland, M. B., Biochim. Biophys. Acta, 16, 288 (1955).
Craine, R. K., and Lipmann, F., J. Biol. Chem., 201, 235 (1953).
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SAGISAKA, S., SHIMURA, K. Mechanism of Activation and Reduction of α-Aminoadipic Acid by Yeast Enzyme. Nature 188, 1189–1190 (1960). https://doi.org/10.1038/1881189a0
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DOI: https://doi.org/10.1038/1881189a0
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