Abstract
CRABTREE'S initial observation that glucose will depress the oxygen consumption of tumour cells has prompted further investigations of this phenomenon, most particularly in Ehrlich ascites cells1 and in reconstructed systems2. It has been recently reported3 that the virus-induced Rous sarcoma on the chorioallantoic membrane of chicken embryos shows a ‘Crabtree effect’. The present communication reports the effect of glucose at various concentrations on the respiration of normal chorioallantoic membrane, and of Rous sarcoma growing on it, and extends the initial observations in this system to other parameters of glucose metabolism.
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LEVINE, A., STRICKER, F., UHL, R. et al. Effect of Glucose Concentration on Respiration of Rous Sarcoma and of Chorioallantoic Membrane. Nature 188, 229–230 (1960). https://doi.org/10.1038/188229a0
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DOI: https://doi.org/10.1038/188229a0
